Friggin' awesome!
HIGHS: Combat rocks - - map is expansive, not on the scale of the previous games, but you really feel the distance between places of interest because you have to actually run there before you can quick travel - - quest system is great, gives you just enough information to force you to figure things out for yourself.
LOWS: Not much here - - could be funnier, missing some of that classic Fallout dark humor - - Rated M but mostly only for gore, little use of foul language (real people swear, even more so after an apocalypse I imagine), not looking for hot coffee, but a little visual or auditory stimulus during say sex with a whore would be better than just waking up next to her.