While you can have an RPG without NPCs, it really defeats the basics of an RPG, what makes an RPG has never really been stats, or equipment, but the interaction with the world around you, and its people.
Thus you see the world in your actions, it reflects the decicions you take, and comments on that is or is not done.
So an RPG without NPCs you can reflect yourself in, and convery the world to you, it will have a hard time being a real RPG, but rather something (adventure/esque in nature).
It is possible if they created the RPG from the ground up, with the story being the questions of where why, and what happened, in those cases, the Envioment takes over the role of an NPC, so it is possible.
Best thing would to have Pc's only so everyone was a living breathing person, but that always gets messed up, since most people have a hard time filling a role, and stay in that role (most people want to assume the role of a hero and a villan, nad it doessnt work, if all in the world is those two things (shopping will be a bi*ch, when the shopkeeper is the dark lord nr. 33 when he is not working.
I am an avid RPG player (both real life, and Pc/console), and I have indeed once created an RPG where the only truely living things in the world was them, and everything else was a grayied out reality, stuck in time, and enemies (altho you can consider those npcs when you think about it).
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