Rogue legacy is amazing as others have mentioned, and although I haven't played them I hear really good things about spelunky, binding of issac and risk of rain if you're into rogue likes.
If you're into old school platformers Volgar the Viking is a great game, also oniken is a pretty cool game that could have been done on the original nes. There is no shortage of good indie platformers though, you could also try giana sisters, mutant muds deluxe, super meat boy, tiny barbarian dx, and angry video game nerd adventures
If you like metroidvania type games valdis:abyssal city is probably my favorite, guacamelee is a great game and castlevania mirrors of fate was very good also, though it does not play like your traditional castlevania, and shantae: riskys revenge is a great game also
If you like diablo style games, the torchlight series(especially 2) are great games as is the adventures of van hellsing
there are tons more but those are the ones I can think of off the top of my head
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