Mass Effect is a solid trilogy. You get the idea of what's happening in ME2 without the first but it makes certain events less meaningful and you'll have no idea what the hell the Reapers are or any other threat that you're facing. Some things are re-explained, others not so much. The characters, including your custom made Shepard, grow and expand through the series and it has heavy focus on characters and past relationships and what not.
Missing the first Uncharted isn't that big of a deal story wise. Sure, you won't immediately know who Sully or Elena are, but after a few words you get the idea. There's one reference Drake says in 2 that refers to 1, but outside of that there's really nothing to know. It's a really simple story. However, the first Uncharted is shamefully overlooked and is still worth experiencing. Especially since it's short, it's a good adventure.
Finally, inFamous 2 will probably fill you in on what Cole did in the first game but the last third of the first game is all story driven to what's going to happen next. It's hard to explain without giving spoilers, but the do blatantly set it up for a sequel and give a lot of importance on the characters and story.
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