Ok thanks a lot for the responses.
For the record, it is Half-Life 2 that is making me sick and it is the sewer and water hazard levels in particular. Although someone mentioned that these were the only levels that made them sick, I don't feel like I even want to take the chance - I gave the game a third try (albeit on the water levels) and almost threw up and now will no matter what not try the game again.
I'm pretty sure that it is the bad framerate on the PS3 version that is doing this, but perhaps the game has an odd frame rate on all versions that causes this as some of you have mentioned that you had this same problem on other versions.
In any event it's good to hear that I'm not the only one with this problem.
Seems like this problem is limited to very few games and pretty much FPS ones.
I'll be trading The Orange Box in for something else and just crossing my fingers that this doesn't happen to me on many other games in the future (probably won't since its only happened to me on two games in like 20 years of playing games).
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