Its not very likely, but if you accidentally do something very wrong it could potentially permanently mess up your game. But I haven't heard any cases of that happening.
Action Replay MAX DUO can't mess your DS, nor the game you are using it with (if it is a DS game). You can just create a back up for your game with it, and the only way you could mess your game would be by disconnection the cable when there's a information exchange between the DS and computer. But JUST THE GAME, could be messed.
Cheating devices can't mess your games, only the use of homebrew can do that. Therefore, that will just happen if you don't know what you are doing.Â
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