Though I've completed No More Heros and have only played Okami for about 5 hours thus far, I can easily say I enjoyed Okami much more. Im a huge fan of adventure games, like Zelda, and Okami fits that perfectly. Your choice though should depend on whether you like Hack n Slash games or Zelda type games.
NMH is a great hack n slash, if you are willing to look past some of the flaws, but pesronally I find it to be one of the best Wii games. Haven't played Okami, so I can't really comment on the gameplay, but you would get more playtime out of Okami.
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