Got mine for Christmas when they first came out with Mario 64, Advanced Wars and Partners in Time. Played Mario 64 first. It was a memorable experience. Brought me back to the 64 days. Good Times.
Honest answer would be halo II. I had bought my DS and had it still in the box and went and played Halo II. My wife got home and was bugging me to open it and play it so I finally did. At that point I think I popped in Advance Wars II for GBA. In case you're getting the wrong impression my DS is my favorite system.
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