Lower tunings, but more tension on the neck. They make hybrid strings now in which the 6th, 5th,4th strings will be as if you have 10-46's and the 3rd, 2nd, and 1st will be 9-42's. I have a Paul Reed Smith in which I use these hybrid strings on. I've used all the way up to 12's before for B# tunings. Overall if you arent going to go any lower than Drop C, I would say the hybrids would be good. Its the best of both worlds.
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