Pay the extra and get the 2x2. There are a number of good reasons for this. Many consumer mobos (even your S2) can have issues with filling all four slots. Really comes down to how well the baord is made as well as the type of RAM you buy and what conditions you use it in. Another reason is less heat to deal with. Four sticks always generate more heat than two and a comon problem with BSOD's is bad or overheated RAM. It also uses less voltage which is part of the reason that two sticks run cooler.
If you decide to go with four sticks all at once then please do the following:
1. Check to see what RAM other S2 users are having good luck with in 4x1 and stick with it.
2. If you cant find that info (although I'm sure a good google will bring it up for you), check the most recent cert table for your board to make sure you get something that works with the most recent BIOS installed on it.
3. If you install an OS after getting the 4x1 RAM, then take two of them out of slots 2 and 4 during the install. Then put them back in after you have the rig setup the way you want it. Again, google will give you many a reason for doing this. In short though, it will help to prevent oddities and problems during the OS install. Trust me.
This is just my opinion on the subject. It's based on tons of empirical evidence I've taken note of in my system builds (which are countless at this point). In no way should you consider it the only option. I have a box with 4x1 of RAM and it's just fine. It's also mixed RAM. It's mixed in speed, size and manufature. 3GB of this: 2x1GB 800 corsair and 2x512MB of 667 OCZ. I was able to get the 667 RAM to run at matched settings with the 800 (tiny OC ^_^) and the box doesnt mind. Just spare parts that I didnt want to go to waste. But far more often than not, I see that 4x1 has issues. Just my opinion on the matter. Good Luck.
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