Kaspersky has the best detection rate of all the non-free AV suites.
For free AV, go with Avira: http://www.free-av.com/
For reference, check out these AV rating sites. Tests different software based on detection rate and other stuff: http://www.av-comparatives.org/ http://www.virus.gr/english/fullxml/default.asp?id=82&mnu=82
The best 3 programs that I have running here spread over a couple of PC's are AVG, Avast and Clamwin. All of them are freeware. AVG is good for above average desktop users, Avast is a bit less hard, Clamwin has lots of options and is used sometimes for servers (it's basically a Linux client with a windows shell) and is more focused on experiences users, it's options are sometimes complicated. Of those 3, all of them have almost the same resource demand footprint, Clamwin being the least resource hog while AVG and Avast being equal in resource usage, a bit higher then Clamwin.
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