Best Format For Compressed Video

I'm looking for the best quality video format to compile all my DVD movies into my media center PC. The video doesn't need to be compressed, it just has to play in Media Player and to be a single file. My main goal is to maintain the best picture. Any suggestions?

I love Xvid but that personally me

you can use MP4 that alright too

Unfortunately I've converted a movie using all these formats and none of them remain identical to VOB. At the highest quality setting, I see blocky video in the blacks and reds.

My goal is to get all my movies into single files rather than multiple VOBs and retain the exact same quality as a standard DVD or better.