It is a good program to clean up your PC, i would suggest running that weekly. I use that program to it cleans up all the bad stuff, but keep in mind if you run the part that cleans the registry it can also break a lot of stuff.
Mechanical HDDs, it's not really needed, but I run defrag on them once a month.
I also peruse the task manager at least once a month to ensure no odd ass programs are running that I don't need or shouldn't be. If I find a program running and I don't know what it is, I'll google it - if it is something I use, it stays. If it is something I don't use or recall having used, I remove it.
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