I would pick the 4890 over the 280.
Hard drive would be your preference. If you can live with 500gb to shave off some from your budget, then go for it. However, it seems like the sweet-spot for price/gb is the 1tb-1.5tb range.
I can't really comment on the motherboard as I haven't looked into X58 setups, but it looks kinda expensive. Depending on your needs you might be able to get something cheaper.
500w should be enough depending on how many drives you'll have in it. If you're gonna load up on multiple hard-drives, then you might need something with more wattage.
And while 2gb of RAM of DDR3 would be the cheaper option, I highly suggest you go for 4Gb (2x 2Gb) as that is becoming standard nowadays.
s0matic
Is there something wrong with the 280? Just wondering.
Yeah, 500GB should be enough, at least for now. And I am already a bit over-budget, and I haven't even included the GPU and Case.
It will only be one HDD with everything else that I listed.
Oh yeah, I forgot about DDR3 haha, because back when I built my own PC, everyone bought DDR2s since they were a lot cheaper.
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