Blood Mage / Arcane Warrior is a very powerful combination, I am just discovering it in my most recent playthrough. Although blood magic uses your life to cast spells, sustained spells like death magic, spell wisp, etc use your mana reserves and not your health so if you build your character right to have lots of life you can gain a greater reserve. Combine that with added defense provided by the Arcane Warriors, and once your life starts to get low you can switch out of blood magic mode and cast force field until your healer heals you.
Blood magic does require a pretty specific build and you need to have a strong party to back you up, from my experience they require a very specific build. Keep in mind too that your first time playing through and getting blood magic you will probably lose Wynne, so you will need a backup healer (default:Morrigan)
Correct me if I'm wrong but I don't think that your fatigue affects the cost of spells if you are using health instead of mana but I'm not 100% sure on this.
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