Here's a few basic ones:
-Get up your small arms skill. They're the most common type of weapon found throughout the game and they're not all that small (like assault rifles).
-Invest in the medicine skill because chances are you will be fighting lots as you progress throughout the game. The higher the medicine the less stimpaks you'll have to consume.
-Shoot all humanoid enemies in the head and don't be afraid to get close.
-Up your repair skill. This is incredibly useful once you get into downtown DC.
-Shoot Centaurs in the legs.
-Explore and search eevrything around you. Supplies are scarce and you need whatever you can get.
-Don't forget to sell your useless items. This really helps early on when you need to buy ammo.
I could keep going on but these are just a few tips i've found work.
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