I would say the G500. But to be completely honest, the best option would be to get a feel for the mice yourself if possible.
The G500 is a heaier mouse from what I felt back then, I like my mice heavy, so that is a preference.
Laser or optical is so so, Im not sure either is a huge sellingpoint. Optical would be good enough for most people anyways.
THe one thing I can not comment on is how sturdy they are, As I said I have a G500, before that a G5.
My own view on the G400 was that it felt light, and fragile. HOWEVER! some of my frinds have G400 mice and they appears as solid and resistant to wear as my G500.
So Basicly see if you can feel them both in your hand, as that will likely be the best for you. In the end it always comes down to feel ;) If you are not able to. You might consider starting with a G400, and IF it is too light, or feels somehow wrong, you could try a G500 next time ;) Just a word of warning, a good mouse is near impossible to wear out, My previous G5, did not break, I still keep it as a reserve ^^
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