It's quite playable with two players and their heroes - you won't be able to do some of the more difficult dungeons due to micromanaging units, but that's a very minor portion of the games.
Each player gets three heroes (and up to four henchmen, preset guys that cannot be directly controlled) that you can allocate skill points and skills and equipment to, control individually via markers and instruct them when to use skills or whether to attack, defend, etc. It's detailed enough that you'll have the two of you plus six almost directly controllable heroes, which will make a lot of the areas much easier than if you just soloed them yourself - which is entirely possible too.
I played most of the three Guild Wars campaigns by myself and enjoyed the hell out of them, plus some two-player, which was a blast.
edit - hero AI is competent enough that it doesn't really become a problem in most cases. When you give them skills, they use the ones closest to the left sideof the bar more often, so the AI is a combination of built-in and what you give them, as skills play a rather important role in the game.
AI healers are almost more effective than human ones - all but the most skilled players, at least.
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