At 1680x1050, the 4850 will probably be at its limit on all high. Anandtech, using the QX9770 in conjunction, was able to get an average of 30 FPS on the 4850 at that res with settings at all high and shaders at very high. With a slower processor, you'd probably have to turn the shaders down to high, then you might be able to have playable frames, depending on what kind of frames you expect. If you're the type who wants a minimum of 30 or 40 frames with 60 average, forget about it. You'd probably need to go to all medium and 1440x900 to accomplish that with a 4850.
I should note, though, that your sig isn't really informative enough of your system. "Core 2 Quad" doesn't tell us specifically what processor you have. Q6600? Q9300? Q9550? That sort of thing. "Asus Mobo" also isn't helpful to anyone who needs to see info on your motherboard should they need to give you advice related to it. You need to tell what model motherboard it is.
Also, if I were you, I wouldn't use a 4850 with that 350 watt PSU. It might be able to run a 4850 on load. Might. And you don't want might, you want definitely. I'd suggest getting a 500W PSU at the least (a good one, not a cheapy); 600W or more if you want to be a little more future proof.
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