There could be several things causing the problem, but as the above said: Heat is likely. You said your fan goes into overdrive... Is that your CPU fan going into overdrive when you do something? If so, it could indicate a problem with cooling. If the thermal paste has crystallized or if there's not enough of it, it'll cause problems in that department.
I'd take off the heatsink and check it. Reapply, if needed, a good thermal paste and check your levels again.
Also, if it's an intermittent problem, it could indicate hardware failure to some degree.
I'd start with the thermal part and go from there.
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