Switch the E8400 to the E7400.
Switch the motherboard to the Gigabyte GA-EP43-DS3L (doesn't save you money unfortunately, but it's a more recent chipset).
Switch that 4x1GB setup to a 2x2GB.
You could save a bit of money with a smaller hard drive.
The power supply you could cut way back on, something in the 550-650w range, like the Corsair TX650w.
The graphics card you could scale back to the HD4850 without any huge loss in performance.
As for your other questions, that setup is not future-proof. Dual-core processors will be outdated as soon as multi-threaded applications take off (probably within the next year or two), Far Cry 2 is already one game that takes advantage of them, and we'll see more games follow suit. The chipset you selected is older, and doesn't support PCI-e 2.0, and LGA 775 is on its last legs anyway. The RAM you picked uses all four slots on your board and doesn't allow room for future expansion, and graphics card technology just moves too quickly for any card to stay realistically competitive. Thinking back four or five years ago, the graphics cards available were the GeForce 6-series and FX-series and Radeon X800 and 9-series, none of which are anywhere close to powerful enough to play modern games well.
And you probably could set core affinity on an older game, but it would be pointless, you're better off just letting Windows handle it.
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