any over clocking is dangerous, so there is no sure amount you can "be safe" with. Whats your cooling situation? If you are unfamiliar with OCing i would definatly start very small and do some research and see what others with the same card have done. But remember there is no sure thing, go little by little and dont push it when you already have a great card and probably great graphics.
I've read many reviews of the EVGA GTX 260 Core 216 SC and none of them have ended up with the same over clocks. In the end it all comes down to; YMMV.
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