I don't run Vista, but from what I hear about the 64-bit version over the 32-bit is that if you're not at least running with 4GB of memory, then you're basically wasting your time.
32-bit only supports up to 3.5GB memory where as the 64-bit can support up to....dang, I don't remember, but it supports a whole heck of a lot more memory.
Just as you'd expect, there are still driver and performance issues that I hear about on the 64-bit version as well as on the 32-bit version. Hopefully and eventually as time progresses, a lot (if not all) of these issues will be addressed and corrected.
I hear some people say they have issues getting games to run on both the 64-bit and 32-bit versions...but like I said above, in time these problems should be corrected.
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