Right now, either the GTX 280 or 9800GX2 would be your best bets. If you can wait a few weeks, the 4870X2 should be better than either of those, albeit at about $550.
EDIT: However, if you want to go Crossfire, two 4850s cost ~$400 and beat both the GTX and the GX2 in most games.
The 4870 gives you the most for your money. But the GTX 280 gives you the best performance. Considering you said you'll pay $400 for the card. Then I recommend you get the GTX 280.
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