Binding of Isaac.
+ Dozens of interesting items to find
+ Smart difficulty curve
+ Tons of unlockables increase replay value
+ Randomized dungeons keep you guessing
- Items lack any description after discovery
- Doesn't offer official controller support
To The Moon
+ Inspiring story will simultaneously break your heart and warm it
+ Great dialogue that punctuates deep emotion with wit and humor
+ Gorgeous music
+ Certain sections cleverly use gameplay to enhance the story
- Some gameplay elements flounder.
I folded and bought To the Moon the other day after reading some praise from RPS chums, it's more interactive fiction than an actual game, but it does it right and doesnt attempt too many gameplay elements just for the sake of it like what other titles like it do.
As for Binding of Isaac, I loved super meat boy, but I dont see the appeal of rogue-like games even though they sounds great to me on paper.
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