When i enable auto save in the game, must i still go back to my safe house and save my progress?
no, but you should still do it. autosave only saves after you're done doing a mission, so if you haven't been doing any missions for a while, you should save at your safehouse just to be safe.
After you complete a mission for example in the left hand corner it will say saving content that is the auto save. Hope this helps...
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