Best GTA so far... already looking forward to the next one!
Gameplay: Almost flawless. The only time I really had any complaints about the control system (that was their fault) was with the cover mechanics. Sometimes Niko would move from one cover to another instead of leaving cover... not a big deal, but it was a little annoying sometimes. Other than that, the control scheme was put together pretty good, although I would recommend using the Standard control setup, because I think it will make it easier to aim & shoot while driving.
The missions are awesome, and the new replay feature makes things a lot easier if you end up dying. The only thing that can get a little frustrating with that is that some of the missions are a lot longer, so if you get 15 minutes into a mission and die, you have to start from the beginning... they don't give you a checkpoint partway through it. But I suppose that's ok too.
Graphics: The attention to detail is just amazing. Tires pop, and then you get 2 lines from the wheels with sparks and everything. You get actual bullet holes in cars. When you run into people, you get blood on the car. There are a couple little hiccups every once in a while with the graphics, and that's the only reason I couldn't give this game a perfect 10.
Multiplayer: Finally they put one of these in a GTA... and it just makes sense. Well made.
Overall: This one gives you a few more choices than you've had in the past, which makes the gameplay experience feel more personal. The characters are better developed, so you really can start to like some of them more than others, which will influence your decisions. Amazing game!