With a huge variety of locales and ways to complete the missions Blood Money is the kind of game you can play over again
Now, with that out of the way, we can get to the main game: this is, without any shadow of a doubt, the best Hitman title to date. The ammount of detail and time put into each individual mission is outstanding, and the interactivity you can finally achive with the NPCs in the game really helps bring it into a more realistic light. The storyline, while interesting with a nice little twist on the end, is a slight bit on the hokey side (what with the attempt to legalize cloning and whatnot) but what really makes Blood Money shine is the open-endedness of it all.
Each mission has several, if not more, ways for you to kill your targets in creative, and sometimes amusing ways. For example, in the second main mission "Curtains Down", you can disguise yourself as one of the opera singers and assassinate one of your targets in plain sight without any suspicion of you, or you can somewhat "trick" the real actor to do it for you, leaving you nowhere near the vicinity when the trigger is pulled.
The look of the game graphically is drastically improved from the likes of Contracts, though it still has some room for improvement, and some of the animations are still somewhat choppy (like when dragging dead/unconcious NPCs and they snag on a door frame, or get crammed into a corner and go flying).
Overall, Blood Money is an amazing, creative, and fun title, and I highly reccomend it to anyone who likes a little stealth with their killin'.