Madden for the Wii has the best gameplay of any football video game to date, period.
The gameplay in Madden NFL 07 for the Wii is extremely intuitive. If you are still having trouble, it has a great tutorial mode that teaches you everything. You actually throw in this game. It feels awesome. All you have to do is hold down the button of the receiver and make a forward motion with the Wii remote. While you are running, you can either stiff arm or juke with either the Wii remote or nunchuck, respectively, by making a motion to the left or right side depending on which way you want the move to go. It just feels so satisfying to actually feel like you are throwing the ball or kicking the ball. One thing that is kind of annoying is when you are trying to select a certain player with the cursor from the Wii remote. It is very touchy and the cursor kind of jolts to other places randomly sometimes. Although this really isn't really a detriment to the gameplay, it is a little irritating. Another thing is the big hit system. In order to do a big hit in any other version of the game, you use the right analog stick to pull off a big hit. On Wii though, you don't have two thumbsticks. So to perform it, you have to hold down the Z button and thrust the nunchuck and Wii remote towards the screen which doesn't feel very natural and is actually difficult to actually come up with a successful big hit. Annoying minor issues aside Madden NFL 07 for Wii has the best gameplay of any Madden to date. The graphics in Madden are a different story. These are slightly higher resolution than Gamecube, but not by very much. This is probably the biggest drawback of the game by far. It is a launch game, and we still don't know what the complete power of the system looks like, but hopefully in the future they will improve the graphics. The animations are really good though, but the main problem is the graphics engine.
The sound is typical Madden. You have John Madden and Al Michaels at the helm commentating. They need to get some new lines though. Their lines are getting kind of old. If you want good Madden commentary, go to Madden 64 for the N64. Incredible lines from John Madden. The sound that comes out of the Wii remote though sound kind of cheap. Overall the sound is the same sound from the other "last-gen" versions.
Madden has the same Superstar, franchise, and play now modes we all know and love, but exclusive to the Wii version are three new mini-games. There is a two on two mini-game where there are two offensive players and two defensive players. Another one is YAC or Yards After Catch where the point is to catch the ball and gain as many yards after you catch it as possible. When you are on defense you have to try and swat the ball and stop the receiver. The last one is the Kicking Combine. This is probably the least fun, because sometimes it says you will slice the ball when your wrist is perfectly straight. Madden for Wii is worth the money.
Overall, Madden for Wii is the best playing Madden ever. If you don't care solely about graphics and you have an open mind to innovation you absolutely cannot go wrong with Madden NFL 07 for the Nintendo Wii.