Try re-installing a few times ...
If you buy this game, you are telling software houses that you don't mind paying full price to rent a game. You are limited to only 3 installs with this game. What are you going to do when the game will no longer run?
Be a good little consumer and buy the latest games instead. Forget about the old ones, they are old news. Now make sure you save harder because buying all these newer games is going to cost you plenty once we have got you used to rent-ware!
I love a good game and I'm sure Mass Effect has some great features. But I utterly reject the deliberate tampering of a game to make it fail after a certain number of installations. PC games have always been made to last a life-time and anything that changes that is no longer a PC Game, it's a rental.