What's the main difference between these two? I consider myself an Agnostic and I get tired of keep being called an Atheist like they mean the same thing. People, I'm serious here!. Agnosticism is NOT a form of Atheism. I will now explain the main difference between them: Atheism claims this: God doesn't exist. Period. Agnoticism claims something that seems to be alike but actually is entirely different: You CAN'T KNOW if God exists or doesn't exists. Period Is that hard? The answer is NO. It's not that hard to see the main difference. Atheism claims what atheists think is the truth and Agnosticism just claims that nobody can really know what the real truth is and therefore nobody can say "God doesn't exist" nor "God exists"... It's like a neutral stance between the affirmation and negation of a plausible existence of a god. I hope this may have helped you to understand the difference. Take care and regards...