It's easy, developers just need to release their PC games on Stardock's Impulse (www.impulsedriven.net) their games have NO DVD/CD protections what so ever, and you don't even need to have impulse started to play the games from there.

But to get patches and other support you need to go online on impulse and download them, effectively locking out the pirates from added content and giving great support to the ones who legitimately bought the game.

It's really amazing that only 1 single developer have really understood what the player needs.
Just take a look at : http://pc.ign.com/articles/920/920382p1.html for a good example on how to deal with piracy....