After watching extensive coverage of E3 on Gamespot these are the games I am most interested in:
Resident Evil 5
Silent Hill 5
Dark Sector
My Sims
Touch Detective 2
Mercenaries 2

Don't know quite how I feel about the Wii fit, I wasn't that impressed with the "zapper" though, looked really cheap and tacky. All I do know is that with all the extra controllers (Wii fit board,steering wheel,zapper,guitar hero guitar,rock band drumkit,singstar microphone,buzz buzzers) you are going to start needing a huge box in your living room to keep them all in.