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Yu Yu Hakusho Ending
I chose this one for number 5 because this series lasted soo long with soo many fans but every good series has to come to an end. The final episode of Yu Yu Hakusho nearly made me cry it was and still is my favorite series of all time, and to see it go was hard. But in the last episode alot of loose ends are tied up, Yusuke confesses his love to Keiko. Hiei seems that he's finally found some one he loves, Kuwabara goes back to school, and Kurama goes back also. Over all this was a really sad time to see this go.
Video here