During the Battle of Sekigahora, a samurai with red eyes appeared. They say he was a demon. His opponent was Misu Kyoshiro. The battle took place under the powers of Sakuya-sama. Kyoshiro powers up and he and Demon Eyes Kyo fight. Sanada Yukimura introduces himself as one who was sent by Sakuya. He asks Kyoshiro if he can hold Kyo longer. Yukimura then asks Saizou to create more mist so that the two fighting won’t be seen.
In the Tokugama leyasu stronghold, the commander is worried and asks if they’ve lost. Both the second and third lines have been defeated. As Sakuya and Yukimura work, a large meteor heads towards the earth. Everyone runs for cover, but Kyoshiro stops and waits. Once the meteor has landed, the commander of the Tokugawa legasu calls to attack now.
Four years later on Nikko Road, Kyoshiro sits by a Wanted sign. The sign is looking for Demon Eyes Kyo, a man with red eyes and a 1.5 meter sword. He is wanted for killing 1000 people and the reward is 1,000,000 Ryos.
Nearby, a woman is lying on the road crying. Now a wandering druggist, Misu Kyoshiro takes her to shelter and nurses her wounds. The woman, Shiina Yuya, pulls out her gun and announces that she is a bounty hunter. He is wanted for eating at Hatago in Kiso and running off without paying. She ties him up for the night. They will set out for the police station tomorrow morning.
A creepy man with a snake tongue comes up behind Yuya. She shoots, but he is able to catch the bullets with his tongue. He changes into a demon. Kyoshiro attacks very ineffectively as the creature taunts him – telling him he’s come a long way to eat him. Kyoshiro gets beat pretty badly in the fight.
Yukimura and Sasuke are hiding in the forest watching this. Sasuke tries to stop the fight, but Yukimura tells him to hold off. He wants to see what will happen. Suddenly, Kyoshiro opens his eyes. They’re blood red. Yukimura throws him his Muramasa, the sword he left behind at Sekigahora four years ago. Demon Eyes Kyo has returned.