My thought?
I would like to see them take their considerable developments skills and work within a T or even E rating. The money is there to be made, and I would consider it more impressive for them to do that than to create another M-title. You can still be creative and poignant without blood, intense violence, partial nudity, strong language, strong sexual content and use of drugs and alcohol (as read off of my GTAIV's ESRB rating), right?