Final Flash

Another one of Vegeta's signature moves (and supposedly the most powerful), he draws his hands back, gathering all of his ki, and thrusts his palms forward, discharging a massive beam of energy towards his opponent.

Vegeta uses this move against Perfect Cell during their battle. Though Cell was significantly more powerful, the sheer amount of energy that Vegeta put into the attack nearly obliterated the overconfident Cell, as well as the entire Earth. Sensing the danger only at the last second, Cell attempted to dodge the beam as the destructive energy disintegrated the ground on which he stood and continued off into deep space. When the dust cleared, Cell had lost his entire upper torso. Despite this, he was able to regenerate himself and continue the fight.

Non-manga usage
In the anime, Vegeta uses this move against the Cell Jr. he is fighting against, but the attack is easily dispatched. He further uses it against Goku while possessed by Babidi (the attack name is heard, but not seen) and then later against a swarm of Buu's while buying time for Goku to charge his spirit bomb.