I just got my second platinum trophy! The first was with Mirror's Edge, and this is for Uncharted: Drake's Fortune.
It actually wasn't as hard as I thought it'd be. Certainly not as hard as Mirror's Edge.
The hardest trophy was beating it on crushing difficulty. But it wasn't as hard as I feared it would be. You tend to notice patterns in the enemy's movements.
I also beat it on crushing without using a sniper rifle, which added to the challenge.
I intend to write a review for Uncharted soon. Overall, I think it gets an 8.5 / 10 from me.