Two ideas...

I know that SLI is very iffy on Vista, and even if you're not using SLI, I agree.. try WinXP with SP2.

Secondly, what's the temperature inside the system like during that game? I know with certain graphics card and 3D Engine combinations the GPU runs hotter than usual. For example, I can run Oblivion at it's lowest settings on my All-in-Wonder, it's choppy, but it doesn't die. Warcraft however (not WoW, just Warcraft) will actually shut down my system after 30 minutes or so, and once I finally get it to turn back on a little voice says "CPU temperature too high." Doesn't make sense but that's how it is. Check the temperature..

DirectX 10 is going to kill Xbox360
cyprusxx

Well, they're both from Microsoft, and XBox was originally the "DirectXBox", so that's really not a good comparison.. however.. I concur, PC will rule.. the only good console is the Wii due to it's WiiMote (which can be used on PC now.. surprise, surprise, we get the best of EVERY world).