This is really hard to predict, a see that some people have choosen Gran Turismo 5, but i really don`t think it has any chance, even if GT5 got a 10.I can`t imagine a racing simulator winning, that said le`ts take a look at the ones i think that can win.

ME2 , HALO REACH , GOD Of War 3, SMG2 ( i really hope not) ,SC2 and Read Dead R.

There are some other games that i think have a small chance such as Heavy Rain and GT5(the underdogs for me).

And of course there is FallOut New Vegas a promissing game , if it is better than the last one it has a great chance of winning GOTY.

Gamespot scores are ussually lower on the pc simply because you need a powerfull pc to play.

If you dont have that kind of machine the game will have bad graphics and low frame rate,but if you have a powerfull one you`ll have better grapgics that the console versions of the game. Pc also allows you to mod and do other stuff, while the consoles have better online support. For online games it depends on the online support but for single player games i use my pc with a xbox 360 control