I'd say Mass Effect 2. Though I was, and still am, in love with Bioshock, I find it hard to imagine how 2k Marin (which lacks a Ken Levine) can repeat the (forgive me for using this word) epic-ness Bioshock had, especially with its story. It's not common to find a game that could place true emotions of fear, loneliness and shock, let alone repeat it in a sequel. Gameplay-wise, Bioshock 2 will probably be an improvement to Bioshock when it comes to the use of Plasmids and guns. Story-wise, it will be hard to recreate or even exceed the impact given by Bioshock.
As for Mass Effect 2, Mass Effect did not really put up a massive amount of impact to its players and so the only pressure ME2 will have will be on how it can create a good story as ME1 and how it will improve the too-simple gameplay of ME1.
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