I actually have the game maxed with all settings and highest AA, and the game runs fine for me.

ASUS SLI-Deluxe Mobo
2GB RAM
BFG GeForce 8800 GTS in 768MB
AMD Athlon X2 4200+

I even edited my files to allow Very High settings to be displayed. Game still runs great, and everything's stock. No OCing here.