You might have heard some of these before, but I thought I'd add them anyway:D

"Haven't I seen you someplace before?"
"Yeah, that's why I don't go there anymore."

He: So what do you do for a living?
She: Female impersonator.

"Is this seat empty?"
"Yes, and this one will be too if you sit down."

"So, wanna go back to my place?"
"Well, I don't know. Will two people fit under a rock?"

"I'd like to call you. What's your number?"
"It's in the phone book."
"But I don't know your name."
"That's in the phone book too."

"What sign were you born under?"
"No Parking."

"I know how to please a woman."
"Then please leave me alone."

"Haven't we met before?"
"Yes, I'm the receptionist at the V.D. Clinic."

"I want to give myself to you."
"Sorry, I don't accept cheap gifts."

"I can tell that you want me."
"Ohhhh. You're so right. I want you... to leave."

"Hey, baby, What's your sign?"
"Stop."

"Hey cutie, how 'bout you and I hitting the hot spots?"
"Sorry, I don't date outside my species."

"May I see you pretty soon?"
"Why? Don't you think I'm pretty now?"

"I'd go through anything for you."
"Good! Let's start with your bank account."

"I would go to the end of the world for you."
"Yes, but would you stay there?"

"Your place or mine?"
"Both. You go to yours and I'll go to mine."

After hearing a pickup line:
I like your approach, now let's see your departure.

Q: Does beauty run in your family?
A: It obviously doesn't in yours!

Q: I think you're the best looking girl in here.
A: Really? Well, I'd better go find the best looking guy then, hadn't I!

Q: Can I buy you a drink?
A: Go ahead, but only if you buy my boyfriend one too!

"I can see forever in your eyes."
Response: "But all I can see is never in yours."

"I looked up beautiful in the thesaurus today and your name was included."
Response: "Thanks! Hey, I saw your name next to jerk."