Title says it all. In cases where the game may release very late this year or early next year, I included 2010.
In no particular order:
inFamous (PS3) - 26 May 2009
This game looks like a lot of fun, even if it may get repetitive. Lightning powers look awesome and the 'Beauty of Power' trailer looks awesome with the slo-mo's.
Modern Warfare 2 (PC, PS3, X360) 10 November 2009
Anyone who played Call of Duty 4 (who doesn't like it?) will probably take a look at this. Simon Wells (brand manager of COD frachise) has said it could be the "biggest selling video game of all time". Now, a lot of people would probably say that, but this is Modern Warfare we're talking about! I'll definately pick this one up for the PC.
Uncharted 2 (PS3) - 2009
What can I say? I loved Uncharted and this one turns out to be looking great.
God of War III (PS3) - 2009/2010
God of War I and II were just plain awesome and I'll want to finish the series and find out what's going to happen after Kratos finishes super-pissed-off mode.
Nice fists.
Prototype (PS3, X360, PC?) - June 2009
This one's a bit like inFamous, but shape shifting powers. Looks really awesome as well in terms of sandbox fun.
I reckon this one'll be just pure awesome.
I know most of these screenshots are IGN - Google images!
That's it for now, all those games look pretty awesome and I'm willing to try them all out at least.
List yours if you read this please.
EDIT: Fixed dates (New inFamous date as at 14 April and Prototype month)