I've only played MGS:PO, but did not feel lost in MGS4. There were some minor references to the past MGS games though. One thing to do would be to go to the forums to read the some of the stickied threads about the history of MGS there.
Well, I play Socom and it would make a difference if you have a microphone and headset for multiplayer, but you would do well without it.
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