Belongs on just about any Top 10 List; Never gets old or boring, runs on any machine, hot seat multiplayer.
Choose an Historical Culture to play, and you take the place of their greatest leader. Explore a pregenerated or custom map, find good spots to found cities, then guide the production of those cities, balancing commerce and defense to build a nation. Then, negotiate with other Leaders, and trade with them, or war with them. Advance your scientific knowledge until you can build a colony ship and settle another planet to win the game.