Not as big of a jump as the others, but not entirely like the SF2 series.
Street Fighter 4 was a very good game in it's own right, but now it'll just be remembered as the framework for something bigger and better. Super has been balanced in such a way that the better player should always win at a low to intermediate level of play. Yes, some matchups are more difficult than others, but there aren't any distinctively cheap characters or tactics here. This makes it fun for everyone and you never feel like you've been cheated out of a win. What this ultimately means is that out of all 35 characters, you should be able to pick the one that feels best and be able to do well after spending a little time with them. There are a few that do take more effort to get the hang of, but it's not impossible to become a decent player using Makoto, Hakan, or even Dan.
As far as controls go, this is typical 2D Fighter fare. The catch is that if you've never really been able to pull of Dragon Punches or command grabs consistently in other games, you probably can now thanks to the more lenient inputs and shortcuts. Elitists and purists may have a problem with this, but being able to pull of a special move easier isn't going to make or break a match. Timing on some of the combos tend to be tricky, but you can practice them all you want in the Training and Challenge modes. Due to the nature of the game being more focused on spacing than huge chain combos in the first place, you may find yourself not even needing them.
My one complaint with the game would be the netplay, which can be spotty if you're playing with someone far away. Otherwise, it's relatively decent and the unavoidable input lag becomes second nature if you let yourself get used it. You'll also run into many of the same characters depending on the time of day (mostly the more easy to grasp but still versatile guys like Ryu), but you can't really fault the game itself for that. Fighters are meant to be played offline anyway, so this can all be avoided easily.
All in all, this isn't my favorite fighter or even my favorite SF game. However, it's impossible to deny the spot on balance wether you like it or not and the tried and true gameplay that the game offers. This is just a distilled, raw representation of what makes fighting games great.