Wario is on DS and he makes great use of the touch screen.
Any fun-loving DS owner should get this game. It's also worth it just to see how many more games you can unlock. Every character has their own specific touch screen movement using the stylus, so you can find someone you like and stick to them. Plus, the animation justs makes you want you laugh. It combines cartoony animation, sketches, real-life, blocky, and a couple more I can't think of.
Nintendo definately made great use of the touch screen when they made Wario Ware Touched for the DS. And for those of you thinking that the game will get boring after you play the microgames for awhile... You're wrong.