Any AC besides Brotherhood, any MGS game apart from MGS4. Oblivion, Dead Space 2, Resident Evil (Prior to RE4). Halo 3, Pokemon Crystal (Gotta have a classic), Devil May Cry 1,3 and 4. Mass Effect 2 used to be there, it's rather meh by your sixth run.
Fallout 3, because you can literally play it for hours on end. New Vegas was cool too but I felt like it was too structured to really just wander and do what you wanted. ME2 is fun to play a few times over I guess. When I was younger I would play Final Fantasy X over and over again until I got sick of it.
Team Fortress 2, BC2. Have spent about 200 hours in each of them, they're games you can just keep coming back too. Mass Effect 2 is getting kinda dull after the 9th playthrough, but I would've said that before.
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