Pokemon Diamond or Pearl have near endless replay value.
Elite Beat Agents and New Super Mario Bros. are also fun to revisit, but they're excitement will die down eventually.
But if you're looking for a long single player campaign then I'd also like to recommend The World Ends with You. If you pace yourself and not try to run through the story, train, and do the missions after the game ends you, then it may last you close to 30 hours.
I am suprised no one mentioned Animal Crossing. That game takes a full year to have a chance at everything in the game (catching all the bugs and fish, going through all the competitions, becoming friends with your neighbors and future neighbors, getting all the fossils/bugs/paintings to fill the museum, so forth and so on). Oh yeah...forgot building your house and furnishing it.
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